About this Event
Activity-based protein profiling – target and ligand discovery on a global scale
Despite advances in our understanding of the genetic basis of human disease, many genes encode proteins that remain uncharacterized and lack selective small-molecule probes. We have introduced activity-based protein profiling (ABPP), a chemical proteomic technology that globally profiles the functional state and small molecule interactions of proteins in native biological systems. In this lecture, I will describe the application of ABPP to generate covalent small molecule interaction (or ligandability) maps of human cells and how this information can guide the discovery of first-in-class chemical probes and drug candidates for disease-relevant proteins.
Keynote SpeakerBenjamin F. Cravatt Professor, The Scripps Research Institute
Dr. Cravatt is Professor and Norton B. Gilula Chair of Chemical Biology in the Department of Chemistry at The Scripps Research Institute. His research group develops innovative chemical technologies that enable protein and drug discovery and applies them to characterize biochemical pathways that play key roles in human physiology and disease. After obtaining a PhD from The Scripps Research Institute (TSRI) in 1996, Professor Cravatt joined the faculty at TSRI in 1997. He is co-founder of several biotechnology companies, including Activx Biosciences, Abide Therapeutics, Vividion Therapeutics, and Belharra Therapeutics, and holds several prestigious honours in the field of chemical biology.
Location
Peter Gilgan Centre for
Research Auditorium
The Learning Concourse | 686 Bay St
Event venue & nearby stays
SickKids Peter Gilgan CRL Auditorium (2-9330), 686 Bay Street, Toronto, Canada
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