Name: Computational Toxicology
Start: 2025-11-10T09:00:00+00:00
End: 2025-11-10T17:00:00+00:00
Location: One Kingdom St

One-day course providing instruction on the use of computational approaches to predict exposure and toxicity in a safety assessment.
About this Event

Computational Toxicology
Practical advice on the use of QSAR models and read across approaches in the ISO 10993-17:2023 standard and ICH Q3E (draft) guideline.

Join Ron Brown, Principal Toxicologist, Risk Science Consortium for a one-day course which will provide instruction on the use of computational approaches to predict the toxicity of data-poor extractable & leachable (E&L) compounds and the rate at which they migrate from pharmaceutical packaging, drug delivery devices, and medical devices. This course will also discuss how to use these model-derived estimates of toxicity and dose in a safety assessment of E&L compounds.

Lunch and coffee breaks included in ticket price.

LEARNING MODULES

When to use computational approaches.

Using open-source exposure models to predict patient exposure to leachables.

Using open-source QSAR models and expert systems to predict toxicological hazards.

Using Read Across and grouping methods to derive Tolerable Intake/Permitted Daily Exposure values.

Using model-derived predictions of exposure and toxicity in a safety assessment.

Hands-on use of models, presentation of case studies, and Q&A.

Agenda

🕑: 09:00 AM - 05:00 PM
Computational Toxicology
Host: Ron Brown