Targeting of the Complement System in Geographic Atrophy

Caroline Baumal, MD

Professor of Ophthalmology

New England Eye Center

Tufts University School of Medicine

Boston, MA

Nathan C. Steinle, MD

California Retina Consultants

Santa Barbara, CA

Geographic atrophy (GA) is an advanced form of age-related macular degeneration (AMD) that results in a progressive and irreversible loss of visual function. Dysregulation of the compliment pathway has been implicated in the development of AMD and GA, and genetic variants of several complement factor genes have been identified as risk factors for these conditions. Currently there are no approved therapies for the management of GA, but promising clinical studies are ongoing to evaluate agents that target components of the complement pathway. These emerging therapies have the potential to delay progression of GA and improve GA outcomes. In this CME activity, experts in the field examine the role of the compliment pathway in AMD as well as evaluate the clinical efficacy of emerging therapies that target the complement cascade for the management of GA secondary to AMD.

Introduction and Pretest

Caroline Baumal, MD

Assessing the Role of Complement in AMD

Caroline Baumal, MD

Emerging Options that Target the Complement Cascade

Nathan C. Steinle, MD

Posttest and Q&A

Upon successful completion of this activity, participants should be better able to:

• Recognize the role of complement in AMD, as well as the mechanism of action behind the activation of the complement cascade and complement inhibition.

• Evaluate the clinical efficacy of emerging approaches that target the complement cascade and have shown promise in the treatment of geographic atrophy secondary to AMD.

The intended audience for this activity is retina specialists and other health care professionals involved in the management of patients with GA.

This continuing medical education activity is provided by Vindico Medical Education.

This activity is supported by an educational grant from Apellis.

Vindico Medical Education is accredited by the Accreditation Council for Continuing Medical Education (ACCME) to provide continuing medical education for physicians.

Vindico Medical Education designates this live activity for a maximum of 1.0 AMA PRA Category 1 Credit(s)™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.

In accordance with the Accreditation Council for Continuing Medical Education’s Standards for Commercial Support, all planners, teachers, and authors involved in the development of accredited content are required to disclose to the accredited provider their relevant financial relationships. Relevant financial relationships will be mitigated and disclosed to the activity audience.

Faculty, topics, program schedule, and credit hours are subject to change. Recording of any manner is prohibited without written permission from the program director and the Office of Medical Affairs and Compliance.

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