Killam Seminar Series: Novel Approaches Against Neurodegeneration

Tue Dec 10 2024 at 04:00 pm to 05:00 pm UTC-05:00

The Neuro. Montreal Neurological Institute-Hospital | Montréal

The Neuro
Publisher/HostThe Neuro
Killam Seminar Series: Novel Approaches Against Neurodegeneration
Advertisement
Novel Approaches Against Neurodegeneration: From Genetic Screens to Antibody-Based Therapeutics
About this Event

Martin Lévesque

Professor, Department of Psychiatry and Neurosciences, Laval University


Novel Approaches Against Neurodegeneration: From Genetic Screens to Antibody-Based Therapeutics

Abstract: Parkinson's disease (PD) is characterized by the progressive loss of dopaminergic neurons in the substantia nigra, leading to motor dysfunction. While the exact cause of PD remains unclear, mitochondrial dysfunction and the accumulation of toxic protein aggregates are thought to play central roles in neuronal death. This presentation discusses two promising neuroprotective strategies. First, a CRISPR-based genetic screen identified Ligase IV (Lig4), a DNA repair protein, as critical for dopaminergic neuron survival. Notably, Lig4 knockout protected neurons from rotenone-induced toxicity in vitro and against neurodegeneration in PD mouse models. Second, the presentation highlights the use of mini-antibodies targeting α-synuclein, which prevent the spread of pathology and the onset of motor dysfunction in a PD mouse model. These findings provide new therapeutic avenues for protecting neurons and potentially modifying disease progression in PD.

Bio: Martin Lévesque is a Full Professor in the Department of Psychiatry and Neuroscience at Laval University and leads a lab at the CERVO Brain Research Centre. He earned his Ph.D. in Neurobiology from Laval University and completed postdoctoral training at the Montreal Clinical Research Institute and the National Institute for Medical Research in London. His research focuses on understanding the cellular and molecular mechanisms that regulate dopaminergic neuronal circuits. His work aims to identify molecules that guide dopaminergic axons, unravel mechanisms of neuron degeneration, and apply these findings to develop diagnostic tools, protective therapies, and cell replacement strategies to regenerate dopaminergic circuits from stem cells. Dr. Lévesque has proven expertise in Parkinson’s disease neurobiology, using both in vivo and in vitro models.

Advertisement

Event Venue & Nearby Stays

The Neuro. Montreal Neurological Institute-Hospital, 3801 Rue University, Montréal, Canada

Tickets

USD 0.00

Discover more events by tags:

Workshops in MontrealNonprofit in Montreal

Sharing is Caring:

More Events in Montreal

D\u00e9coration de sac \u00e0 motifs berb\u00e8res
Tue Dec 10 2024 at 10:00 am Décoration de sac à motifs berbères

7070 Rue Jarry E, Montréal, QC H1J 1G4, Canada

Exposition Les passantes
Tue Dec 10 2024 at 11:00 am Exposition Les passantes

Galerie Le 1040

Sant\u00e9 pelvienne apr\u00e8s la m\u00e9nopause
Tue Dec 10 2024 at 12:00 pm Santé pelvienne après la ménopause

Bibliothèque du CHUM

Projections of sea ice conditions in Nunatsiavut (Labrador)
Tue Dec 10 2024 at 12:30 pm Projections of sea ice conditions in Nunatsiavut (Labrador)

UQAM Pavillon Président-Kennedy (PK)

LES MARDIS PM - BEMOL 9 CHANTE NO\u00cbL
Tue Dec 10 2024 at 03:00 pm LES MARDIS PM - BEMOL 9 CHANTE NOËL

10300 rue Lajeunesse, 1er étage, Montreal, QC, Canada, Quebec H3L2E5

RB Salzburg - PSG avec le PSG Club Montr\u00e9al
Tue Dec 10 2024 at 03:00 pm RB Salzburg - PSG avec le PSG Club Montréal

429 avenue Viger Est, Montreal, QC, Canada, Quebec H2L 2N9

[ FORMATION ] Sc\u00e9narisation d\u2019exp\u00e9riences immersives
Tue Dec 10 2024 at 06:00 pm [ FORMATION ] Scénarisation d’expériences immersives

Société des arts technologiques [SAT]

Global Book Club Ft. Shahrnush Parsipur's WOMEN WITHOUT MEN
Tue Dec 10 2024 at 06:30 pm Global Book Club Ft. Shahrnush Parsipur's WOMEN WITHOUT MEN

Librairie Saint-Henri Books

Montreal Singles Mixer\/ Ages 25+
Tue Dec 10 2024 at 07:00 pm Montreal Singles Mixer/ Ages 25+

Satay Brothers Resto 3721 Notre-Dame

Shakira
Tue Dec 10 2024 at 07:30 pm Shakira

Centre Bell Montréal

Kent Nagano @ Place des Arts - Maison Symphonique in Montr\u00e9al
Tue Dec 10 2024 at 07:30 pm Kent Nagano @ Place des Arts - Maison Symphonique in Montréal

Place des Arts - Maison Symphonique

Sci-Fi Showcase
Tue Dec 10 2024 at 07:30 pm Sci-Fi Showcase

Théâtre Paradoxe

Montreal is Happening!

Never miss your favorite happenings again!

Explore Montreal Events