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Clonazepam should be used with caution in certain populations, including:

• Individuals with a history of substance abuse or dependence
• Patients with severe respiratory insufficiency or sleep apnea
• Pregnant or breastfeeding women
• Elderly patients
• Patients with hepatic or renal impairment

Clonazepam is not recommended for use in children under 18 years of age for the treatment of panic disorder and should be used with caution in this population for the treatment of seizure disorders.

As with other benzodiazepines, clonazepam has the potential for dependence and withdrawal if used for long periods or at high doses. Physical dependence may develop with prolonged use, leading to withdrawal symptoms if the Medic*tion is abruptly discontinued. Withdrawal symptoms may include:

• Anxiety
• Insomnia
• Irritability
• Tremors
• Sweating
• Muscle cramps
• Seizures (in severe cases)

To minimize the risk of dependence and withdrawal, clonazepam should be used as directed by a healthcare provider and gradually tapered off when discontinuing treatment.

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