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Uveal melanoma (UM) displays a high frequency of metastasis; however, effective therapies for metastatic UM are limited. Identifying unique metabolic features of UM may provide a potential targeting strategy. A lipid metabolism protein expression signature was induced in a normal choroidal melanocyte (NCM) line transduced with GNAQ (Q209L), a driver in UM growth and development. Consistently, UM cells expressed elevated levels of fatty acid synthase (FASN) compared to NCMs. FASN upregulation was associated with increased mammalian target of rapamycin (mTOR) activation and sterol regulatory element-binding protein 1 (SREBP1) levels. FASN and mTOR inhibitors alone significantly reduced UM cell growth. Concurrent inhibition of FASN and mTOR further reduced UM cell growth by promoting cell cycle arrest and inhibiting glucose utilization, TCA cycle metabolism, and de novo fatty acid biosynthesis. Our findings indicate that FASN is important for UM cell growth and co-inhibition of FASN and mTOR signaling may be con🌟 Prepare for an extraordinary experience at Rose Wagner Performing Arts Center - Jeanne Wagner Theatre for Anna Han, a mesmerizing Classical event that promises to redefine your expectations. From captivating presentations to interactive showcases, this Concert in Utah, United States is designed to leave you inspired and amazed. Join us for this incredible event 🚀.
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Rose Wagner Performing Arts Center - Jeanne Wagner Theatre, Rose Wagner Performing Arts Center - Jeanne Wagner Theatre, Salt Lake City, Utah, United States
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