Name: Anna Han
Start: 2024-09-27T19:30:00-07:00
End: 2024-09-27T21:30:00-07:00
Location: Jeanne Wagner Theatre At Rose Wagner PAC

Uveal melanoma (UM) displays a high frequency of metastasis; however, effective therapies for metastatic UM are limited. Identifying unique metabolic features of UM may provide a potential targeting strategy. A lipid metabolism protein expression signature was induced in a normal choroidal melanocyte (NCM) line transduced with GNAQ (Q209L), a driver in UM growth and development. Consistently, UM cells expressed elevated levels of fatty acid synthase (FASN) compared to NCMs. FASN upregulation was associated with increased mammalian target of rapamycin (mTOR) activation and sterol regulatory element-binding protein 1 (SREBP1) levels. FASN and mTOR inhibitors alone significantly reduced UM cell growth. Concurrent inhibition of FASN and mTOR further reduced UM cell growth by promoting cell cycle arrest and inhibiting glucose utilization, TCA cycle metabolism, and de novo fatty acid biosynthesis. Our findings indicate that FASN is important for UM cell growth and co-inhibition of FASN and mTOR signaling may be con
🗓️ Mark your calendar at Jeanne Wagner Theatre At Rose Wagner PAC. Anna Han is a celebration of passion, innovation, and community. Embrace the opportunity to explore the world of various interests in a dynamic setting in Utah, United States. Don't miss out on this remarkable event 🌈. http://maps.seatics.com/JeanneWagnerTheatreAtRoseWagnerPAC_Endstage2_2024-03-08_2024-03-08_1840_03082024_113345_SVGC_tn.png