Leki na raka sprzedam cytostatyki nowotwor przeciwrakowe terapia nowotworow

Leki przeciwpasożytnicze przeciwgrzybicze antybiotyki terapie antynowotworowe w leczeniu raka alternatywne eksperymentalne leki rak nowotwór tarczycy prostaty wątroby skóry płuc jelita grubego piersi jajnika kości mózgu odbytu wątrobowokomórkowy kory nadnercza ostra białaczka szpikowa głowy i szyi podstawnokomórkowy skóry trzustki szpiczak mnogi kostniakomięsak mięsak rdzeniak glejak wielopostaciowy kolczystokomórkowy skóry głowy i szyi płaskonabłonkowy przełyku przewlekła białaczka szpikowa raki systemu trawiennego moczowego krwi reprodukcyjnego glejak mózgu czerniak

GRYZEOFULWINA

Działa na większość rodzajów raka. Dawkowanie 500g 3x dziennie

https://www.cancertreatmentsresearch.com/griseofulvin-like-chemotheraphy-but-without-its-side-effects/

KETOKONAZOL

Rak prostaty

https://prostatecancer.net/treatment/nizoral-reviews-how-well-works-side-effects

"The role of ketoconazole in current prostate cancer care"

https://pubmed.ncbi.nlm.nih.gov/30154429/

Wątroby

"Ketoconazole suppresses the growth of hepatocellular carcinoma"

https://www.tandfonline.com/doi/abs/10.1080/15548627.2019.1569934

VERMOX MEBENDAZOL

Wiele różnych nowotworów "Mebendazole a well-known anti-helminthic drug in wide clinical use has anti-cancer properties that have been elucidated in a broad range of pre-clinical studies across a number of different cancer types. Significantly there are also two case reports of anti-cancer activity in humans." Dawkowanie minimum 2x100mg

"Repurposing Drugs in Oncology (ReDO)—mebendazole as an anti-cancer agent"

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4096024

https://www.cancertreatmentsresearch.com/the-over-the-counter-drug-mebendazole-acts-like-chemotherapy-but-with-virtually-no-side-effects/

Kostniakomięsak mięsak rak skóry płuc jelita grubego piersi jajnika wątrobowokomórkowy kory nadnercza ostra białaczka szpikowa glejak wielopostaciowy rdzeniak.

"Preclinical studies show that mebendazole notably impedes the growth of malignant and metastatic tumors such as osteosarcoma and soft tissue sarcoma melanoma carcinoma (lung colorectal breast ovarian hepatocellular and adrenocortical) acute myeloid leukaemia glioblastoma multiforme and meduloblastoma."

"Application of a widely-used tropical anti-worm agentmebendazole in modern oncology"

https://www.ajol.info/index.php/tjpr/article/download/162964/152474

Nowotwór mózgu https://abc2.org/research/projects/repurposing-antiparasite-drug-fight-glioblastoma

Nowotwór mózgu przykład:

"The drug cocktail is prescribed by Care Oncology a private clinic in London which recommends a statin (a cholesterol-lowering drug) metformin (used to treat type-2 diabetes) doxycycline (an antibiotic) and mebendazole (an anti-worming agent). These may sound radical but are actually safe cheap generic medicines with evidence of some anti-cancer effects."

https://www.economist.com/international/2019/02/28/repurposing-off-patent-drugs-offers-big-hopes-of-new-treatments

Trzustki

"“We are advocating for use of mebendazole as a therapy for those diagnosed before metastasis to see if we can slow or prevent pancreatic cancer” Riggins says. “For those with more advanced cancers it could be an alternative to certain surgeries. Mebendazole may have utility as a therapy after initial treatment to prevent tumor recurrence in the 15% to 20% of pancreatic adenocarcinoma patients who undergo surgery. It may also increase the durability of response to standard chemotherapy in the remaining 80% to 85% of patients with advanced disease.”

https://www.hopkinsmedicine.org/news/newsroom/news-releases/johns-hopkins-study-anti-parasitic-drug-slows-pancreatic-cancer-in-mice

Tarczycy

Zapobiega guzom tarczycy do przerzutów do płuc.

"In vivo mebendazole treatment resulted in significant orthotopic thyroid tumor regression

(B-CPAP) and growth arrest (8505c) with treated tumors displaying reduced expression

of the proliferation maker KI67 and less vascular epithelium as indicated by CD31+

immunohistochemistry. Most importantly daily oral mebendazole prevented established

thyroid tumors from metastasizing to the lung. Given the low toxicity and published

anticancer mechanisms of mebendazole this novel preclinical study of mebendazole

in thyroid cancer has promising therapeutic implications for patients with treatment

refractory papillary or anaplastic thyroid cancer"

"Mebendazole inhibits tumor growth and prevents lung metastasis in models of advanced thyroid cancer"

https://erc.bioscientifica.com/downloadpdf/journals/erc/27/3/ERC-19-0341.xml

Przykład rak odbytnicy z przerzutami remisja po 42 dniach mebendazol 200mg dziennie:

"Colon cancer patient with liver and lung metastases; the patient was treated conventionally with capecitabine oxaliplatin and becacizumab but failed largely due to oxaliplatin-induced neuropathy [371]. Mebendazole therapy (200 mg daily) was continued for 42 days and there were near complete remission of the metastases in the lungs and lymph nodes and a good partial remission in the liver"

"Tumour remission by the antihelmintic drug mebendazole in refractory metastatic colon cancer"

https://www.tandfonline.com/doi/full/10.3109/0284186X.2013.844359

Przykład rak kory nadnerczy z przerzutami do wątroby dawka 200mg dziennie przez 19 miesięcy regresja i stabilizacja przerzutów:

"The patient was a 48-year-old man with adrenocortical carcinoma with liver metastasis and conventional treatments with mitotane 5-fluorouracil streptozotocin bevacizumab and radiation therapy failed and were intolerable [370]. Mebendazole (200 mg daily for 19 months) brought about regression of hepatic metastatic lesions with subsequent stability for 19 months although the disease progressed after 24 months; however the patient had no clinically adverse effects and the quality of life was satisfactory [370]. A combined use of mebendazole with other cytotoxic drugs was suggested to have synergistic effects"

"Mebendazole monotherapy and long-term disease control in metastatic adrenocortical carcinoma"

https://pubmed.ncbi.nlm.nih.gov/21454232/

ITRAKONAZOL

Rak prostaty płuc podstawnokomórkowy skóry. Możliwe białaczka rak jajnika piersi trzustki. Może wzmacniać inne leki.

"Clinical trials have shown that patients with prostate lung and basal cell carcinoma have benefited from treatment with itraconazole and there are additional reports of activity in leukaemia ovarian breast and pancreatic cancers. ... Itraconazole may synergise with a range of other drugs to enhance the anti-cancer effect and some of these possible combinations are presented in the supplementary materials accompanying this paper."

"Repurposing Drugs in Oncology (ReDO)—itraconazole as an anti-cancer agent"

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4406527/

NIKLOZAMID

Rak piersi prostaty jelita grubego jajnika szpiczaka mnogiego mózgu ostra białaczka szpikowa płuc głowy i szyi.

"Anti-cancer activity of niclosamide has been demonstrated in human breast cancer prostate cancer colon cancer ovarian cancer multiple myeloma acute myelogenous leukemia glioblastoma head and neck cancer and lung cancer cells"

"Multi-targeted therapy of cancer by niclosamide: a new application for an old drug"

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4166407/#S9title

Białaczka rak piersi prostaty wątroby mózgu.

"Potential anticancer agent that exerts cytotoxic and cytostatic activity against a wide range of cancer types including leukemia breast cancer prostate cancer hepatocellular carcinoma and glioblastoma. Additionally it has shown anti-invasive and anti-migratory effects."

"Drug Repurposing of the Anthelmintic Niclosamide to Treat Multidrug-Resistant Leukemia"

https://www.frontiersin.org/articles/10.3389/fphar.2017.00110/full

IWERMEKTYNA

Rak jajnika piersi płaskonabłonkowy przełyku przewlekła białaczka szpikowa raki systemu trawiennego moczowego krwi reprodukcyjnego glejak mózgu czerniak i płuc. Jest skuteczna przeciwko szerokiej gamie nowotworów i ma wiele efektów.

"It has proven to be fairly effective against a large variety of cancers. The types of cancers it worked against included ovarian cancer breast cancer Oesophageal Squamous Cell Carcinoma. Ivermectin has also been verified as being useful in inducing apoptosis in chronic myeloid leukemia. ... There are a large number of other cancers that ivermectin is highly useful for including cancers of the digestive system cancers in the urinary tract hematological cancers other than CML cancers in the reproductive system brain glioma melanoma and lung cancers. All the trials and researches mentioned have shown that Ivermectin is effective against a vast variety of tumors and has multiple effects.

http://i2b.us/anti-parasite-drug-ivermectin-shows-promise-against-cancer/

"Ivermectin has powerful antitumor effects including the inhibition of proliferation metastasis and angiogenic activity in a variety of cancer cells. ... Can also inhibit tumor stem cells and reverse multidrug resistance and exerts the optimal effect when used in combination with other chemotherapy drugs.

"Ivermectin a potential anticancer drug derived from an antiparasitic drug"

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7505114/

DISULFIRAM

Rak piersi

"Disulfiram combats cancer"

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6089232

Rak kości prostaty piersi jelita grubego:

"Of the more than 3000 patients taking Antabuse the cancer death rate was 34% lower for the 1177 who stayed on the drug compared with those who stopped taking it the researchers report today in Nature. The drug was an equal opportunity anticancer weapon; its benefits held for prostate breast and colon cancer as well as cancer overall."

https://www.sciencemag.org/news/2017/12/old-drug-alcoholism-finds-new-life-cancer-treatment

Rak kolczystokomórkowy skóry głowy i szyi

"Anti-cancer effects of disulfiram in head and neck squamous cell carcinoma"

https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0203069

DOKSYCYKLINA

Nowotwór mózgu

https://www.economist.com/international/2019/02/28/repurposing-off-patent-drugs-offers-big-hopes-of-new-treatments

ZENTEL ALBENDAZOL

Rak jajnika "A single dose of albendazole (150 mg/kg) dramatically suppressed tumor levels of both VEGF and HIF-1"

https://angio.org/drug-used-to-treat-parasites-may-have-tumor-fighting-antiangiogenic-properties

Zaawansowany rak dawka 2x1200mg dziennie przez 14 dni:

"Research institutions have already carried out phase I clinical trials of oral ABZ to treat advanced cancer patients to detect it's maximum tolerated dose. Results from the 36 patients with refractory solid tumors enrolled in the study showed that the recommended dose for further study was 1200 mg twice daily for 14 days in a 21-day cycle with myelosuppression being the main dose-limiting toxicity (64). Although no patients achieved partial or complete response according to the RECIST study’s criteria 4 out of 24 patients with assessable tumor markers (16%) demonstrated a decrease in tumor markers of more than 50%. In contrast another patient had a signiﬁcant decrease in tumor markers and a prolonged period of stable disease. Overall as research continues to progress new anticancer drugs based on ABZ can be expected".

"Phase I clinical trial to determine maximum tolerated dose of oral albendazole in patients with advanced cancer"

https://link.springer.com/article/10.1007/s00280-009-1157-8

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