Harmonising single-cell RNA from ~30 million cells from 45 anatomical sites to create a map of the healthy immune systemAbout this Event
From the Human Cell Atlas to the Body Map of the Immune System
Understanding tissue biology’s heterogeneity is crucial for advancing precision medicine. Despite the centrality of the immune system in tissue homeostasis, a detailed and comprehensive map of immune cell distribution and interactions across human tissues and demographics remains elusive. To fill this gap, we harmonised data from 12,981 single-cell RNA sequencing samples and curated 29 million cells from 45 anatomical sites to create a comprehensive compositional and transcriptional healthy map of the healthy immune system. We used this resource and a novel multilevel modelling approach to track immune ageing and test differences across sex and ethnicity. We uncovered conserved and tissue-specific immune-ageing programs, resolved sex-dependent differential ageing and identified ethnic diversity in clinically critical immune checkpoints. This study provides a quantitative baseline of the immune system, facilitating advances in precision medicine. Stefano will also present the methods and software infrastructure that were implemented to allow such large-scale data modelling in this talk.
Date/Time:
Wednesday 9 October 2024
3:30pm - 5:00pm
Location:
G030 Lecture Theatre (ground floor)
Adelaide Health and Medical Sciences Building
Speaker Information:
Dr Stefano Mangiola
Group Leader, Computational Cancer Immunogenomics
SAiGENCI – South Australian immunoGENomics Cancer Institute
Snack and Refreshments will be provided - Thank you to our Event Sponsor Decode Science
About Our Speaker:
Stefano leads the Computational Cancer Immunology Group at SAiGENCI. His research spans immunodiagnosis of metastatic breast and prostate cancer, AI and biostatistics application to cancer immunology, and large-scale data analysis pipelines. His translational work focuses on profiling the local and systemic cancer microenvironment with spatial and single-cell technologies and studying the patient’s immune system with analytical and AI tools to inform on therapy resistance in cancer.
Event Venue
Adelaide Health and Medical Sciences building - The University of Adelaide (Room G030), 4 North Terrace, Adelaide, Australia
AUD 0.00
